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Shepherd, BMI is one key factor in determining eligibility, with most participants having a BMI of 30 or higher

Taken together, evidence from the STEP, SURMOUNT, and S-LiTE trials strongly supports the lifestyle interventions, particularly dietary modification and structured exercise, being not only compatible with but also additive to the effects of GLP-1 therapies

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This condition is central to the pathophysiology of type 2 diabetes and is often associated with obesity, physical inactivity, and metabolic syndrome

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It remains to be investigated whether cardiovascular protective effects of GLP-1RAs can also be independent of the known effects on glucose metabolism