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The closest structural relative was found to be human CLIC1 (PDB code 1K0O), in which 156 C could be aligned with a root-mean-square deviation (RMSD) value of 0.93 , followed by GSTO1 from Homo sapiens (PDB code 3LFL) (122 aligned C with an RMSD of 2.07 ) and the putative stringent starvation protein A from Burkholderia cenocepacia (PDB code 4QQ7) (122 aligned C with an RMSD of 2.14 ) 12,15

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Nat Rev Endocrinol 20(11):647660 Larsen PR (2015)

Peptides stimulate the pituitary gland and hypothalamus to produce its own HGH, so they keep the pituitarys negative feedback loop involved, which keeps the pituitary gland from burning out