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However, melatonin is not exclusively produced in the pineal gland, but it is also locally synthesized in several cells and tissues, such as the retina, the gastrointestinal tract, and the innate immune system 10

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 20% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Current human safety data obtained under approved therapeutic regimens are characterized predominantly by mild-to-moderate gastrointestinal adverse events rather than generalized cytotoxic toxicity, underscoring the need to distinguish preclinical pro-apoptotic observations from clinically established safety profiles

Public health implications of legalising the production and sale of cannabis for medicinal and recreational use