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Fasting levels of blood glucose (n = 8 each group) (m) and insulin (n = 6 WT, n = 7 KO) (n) in 54-week old female WT and KO mice, as well as fasting plasma levels of triglycerides (n = 6 WT, n = 7 KO) (o) and cholesterol (n = 6 WT, n = 7 KO) (p) in 55-week old female WT and KO mice

Whether the same magnitude of risk reduction occurs in a population with inherited cardioprotection remains unknown, as the low baseline risk may attenuate absolute benefits - a phenomenon known as a ceiling effect

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