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Clinical guidelines for prevention and treatment of type 2 diabetes in the elderly in China (2022 Edition)

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Semaglutide (GLP-1 mono-agonist) typically delivers around 14.9% loss at 68 weeks in STEP 1, against roughly 22.5% for tirzepatide 15 mg in SURMOUNT-1 [4]

93 In the randomized clinical trial STEP-HFpEF, patients who did not have T2D were assigned to either semaglutide 2.4 mg once weekly or placebo and followed for 52 weeks