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Patients with more severe GI side effects can also often tolerate the medication better when it is uptitrated more slowly than the typical titration protocol

[8] Interestingly, vitamin B12 deficiency has similar symptoms to diabetic neuropathy, which affects an estimated 40 to 50 percent of those with type 2 diabetes at some point

Blinding may have been compromised in the semaglutide group, because people tend to notice when they lose ~14% of their body weight

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