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[DOI] [PMC free article] [PubMed] [Google Scholar] Fortuo A, San Jos G, Moreno MU, Beloqui O, Dez J, Zalba G

Since Sirtuin 3 (SIRT3), the major NAD+-dependent deacetylase, is primarily expressed in neurons [31] and is exclusively located in the mitochondria [41], it plays an important role in regulating mitochondrial function, metabolism, antioxidative defense systems, and energy metabolism [42]

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GSH actively attends to oxidative free radicals and, in doing so, becomes oxidized and converts to the inactive GSSG

134 , e176910 (2024)

194 This result was consistent with the accumulation of CSA in patient-derived low-grade glioma and with the intra-tumoural expression of CDO1, 76 since the decreased level of cysteine can be due to the overexpression and activity of CDO1 found in high-grade glioblastomas