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How it compares: Average loss is smaller than GLP1s (e.g., one NMA: ~4.6% with NB vs ~13.7% with semaglutide ), but its a pill and may fit better for some people (JMCP, 2023

In a clinical trial of more than 1,700 men and women, which was sponsored by the drugs manufacturer, those taking Contrave lost 5.4% of their body weight on average over the 56 weeks they were tracked

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