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The approval for Novos first RNAi therapy was based on data from the pivotal Phase II PHYOXTM2 trial and interim data from the ongoing Phase III PHYOXTM3 extension study

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For this purpose, we used T1w (available in FSL) and magnetic resonance angiography (MRA) maps [42] in the MNI space with 2-mm isotropic resolution to extract anatomical ROIs for the pituitary gland and the nearby internal carotid arteries