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The most common side effects are gastrointestinal, including: Nausea Diarrhea Vomiting Constipation These are dose-dependent and usually mild to moderate
The "Muscle Loss" Concern: Recent 2025-2026 data emphasizes the importance of high protein intake and resistance training on these meds to prevent losing too much lean muscle mass
These changes happen because GLP-1 receptors are located not just in the gut, but throughout the central nervous system, including areas controlling memory and executive function
Several studies have established that autistic individuals experience a loss of neuronal 7nAChRs in the hippocampus, cerebral, and cerebellar cortex [13, 33, 34]
Haroon, S
Some find that applying ice to the injection site for a brief period before injection provides temporary numbing, though this should be balanced against the recommendation to use room-temperature medication
