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Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]

Start each separately to understand individual effects first

However, due to the large molecular size, topical glutathione may have limited skin penetration, though it can still support skin health when combined with other active ingredients like vitamin C, kojic acid, or niacinamide