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It is often used to justify a diagnostic colonoscopy following a positive screening test

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CYP2D6 exhibits a marked genetic polymorphismover 70 alleles (www.cypalleles.ki.se/cyp2d6.htm) have been described whose combination leads to four phenotypes: poor, intermediate, extensive, and ultrarapid metabolizers (PM, IM, EM, and UM, respectively)

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In particular, GSTT1-1 and GSTM1-1 null genotypes, as well as GSTP1-1 variants, were studies and showed a positive correlation with cancer risk (Table 1) 24,32,35,36,37,38,39,40,41,42

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