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Whilst the MHRA does permit access to unlicensed medicines in limited circumstances for example, through the Specials framework or on a named-patient basis these routes apply to medicines that are not licensed in the UK but are manufactured or available elsewhere

Some patients benefit from a staged approach with procedures spaced several months apart

So essentially the cats out of the bag, its already happening

A Cochrane systematic review of randomized trials for melasma found combination therapy more effective than single agents (a Cochrane systematic review of randomized trials for melasma), and a study in Middle Eastern skin confirmed a tretinoin and hydroquinone combination was effective and tolerated in deeper skin tones (a study of a hydroquinone and tretinoin combination for melasma in deeper skin tones)

Most commercial plans will require prior authorization

Research Diets, no