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Yes, untreated vitamin B12 deficiency can cause irreversible neurological damage, particularly affecting peripheral nerves and the spinal cord

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Biomed Pharmacother 57:145155

Winklhofer KF, Haass C (2010) Mitochondrial dysfunction in Parkinsons disease

Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer's disease

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