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Furthermore, the study suggests that GHK-Cu could potentially influence the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway

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A rat AD model was established by injecting A4 into the bilateral lateral ventricle of rats, which resulted in a decrease in acetylcholine content and acetylcholinesterase activity

NTvG 2002;146: 459-64 5

They have to be converted to the active form and are less potent than the pure, active ingredient. The difference between pure vitamin C and vitamin-C derivatives is similar to retinols and retinoids: Both work, but one is more concentrated and thus more effective

Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on January 3rd, 2026