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The more responsible approach is to address the systems that actually shape brain aging: metabolic health, cardiovascular risk, sleep, movement, body composition, inflammation, sensory health, hormones, nutrition, and long-term function

doi:10.1016/j.molmet.2024.101880 Publication Licenses Figure 1: Created in BioRender

Adequate nutrient intake is needed to help prevent conditions like malnutrition and sarcopenia

Experts now specify the following fiber targets for those on a GLP-1: 25 g/day of fiber for women, 30 g/day for men and 35 g/day for those with diabetes (Sievenpiper et al 2026) Healthy fats found in olive oil, nuts, seeds, avocado, fatty fish Hydration: 23 L/day for digestion, bowel health, kidneys and energy, up to 4 L/day depending in climate and activity

DPP-4 inhibitors-renoprotection in diabetic nephropathy

When exposed to a hyperglycemic milieu, the GIPR was found to downregulate in a study of pancreatic islet cells (59) and the patients with T2DM might express a small amount of GIPR or defective GIPR (60, 61)