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Translationally, redox proteomics (cysteine-switches in insulin signalling), Prx redox state, F 2 -isoprostanes/HNE adducts and LIP assays (with chelator validation) help stratify patients and monitor interventions such as mitochondrial quality control, NOX isoform targeting and dietary/exercise prescriptions that reset redox tone without erasing adaptive signalling (Holendov et al

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