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In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

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Dormancy is further stabilized by intrinsic regulators such as lncRNA NR2F1-AS1, which regulates stemness to prevent metastatic activation, and laminin-211 from the astrocytes in the brain, which maintains quiescence through dystroglycan signaling (163)

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Metabolic Health : Favorable effects on lipid profiles, with reductions in triglycerides and LDL cholesterol, alongside improvements in markers of systemic inflammation