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In the early 2000s, several cases of liver toxicity related to kava consumption were reported ( The Food and Drug Administration (FDA) later warned about the risk of liver damage associated with products containing kava ( Its use has even been banned or restricted in many countries, including Germany, Switzerland, France, Canada, and the United Kingdom

Age, baseline metabolic health, hormone levels, diet adherence, exercise consistency, sleep quality, and stress levels all play roles

Secondary mechanisms include modulation of inflammatory cytokines and interaction with growth factor receptors, contributing to its broad regenerative profile in research models focused on musculoskeletal, gastrointestinal, and neural tissues