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Cell death in the substantia nigra is a classic feature of PD

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doi: 10.1016/j.arcmed.2021.03.006 153 NasiriNMoiniAEftekhari-YazdiPKarimianLSalman-YazdiRArabipoorA

Their potential interactions with both hypothalamicpituitary pathways and peripheral metabolic markers continue to be evaluated, although the mechanistic basis of the blend remains an active area of study

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