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A two-year clinical trial designed to assess the effect of lipoic acid on loss of mobility and changes in brain volume in patients with progressive multiple sclerosis is ongoing

These studies together suggest a framework for understanding AHK-Cunot as an isolated molecule, but as part of a broader family of metalpeptide therapeutics that interact dynamically with living systems

doi: 10.1016/j.bbamcr.2008.05.007

For instance, a phase II trial assessed the weight loss properties of tesofensine in obese patients and found significant reductions in body weight and visceral fat

Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial