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Clin Transl Immunol (2022) 11(8):e1414

Modulation of insulin resistance in nonalcoholic fatty liver disease

Many compounds have shown a beneficial role in reducing oxidative stress due to their free radical scavenging properties, indirect antioxidant properties, or anti-inflammatory actions

Biochimie (2017) 136:216

In MASLD, elevated SAA levels may reflect hepatic inflammation and the resulting tissue damage associated with this inflammatory process [209]

During the subsequent repair phase, HMGB1 facilitates these cells to transition to a tissue repair phenotype and suppresses the secretion and accumulation of inflammatory factors, ultimately promoting tissue healing [243]