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The selenium group showed no change in TSH levels

Calorie or carbohydrate restriction

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Among the most promising markers there are: urinary melatonin metabolites (such as 6-sulfatoxymelatonin or aMT6s), salivary or serum cortisol profiles, DNA methylation signatures in clock and tumor suppressor genes, telomere elongation patterns, and altered circulating microRNAs (miRNAs) levels 32,33

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At lower, sub-toxic concentrations, sulforaphane increased NRF2-mediated antioxidant defenses, ultimately enhancing neuronal survival in cell culture models driven by oxidative and inflammatory insults (Table 2) (Vauzour et al., 2010