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Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy

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Additionally, another study identified edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one, EDA) as an inhibitor of neuronal cell ferroptosis through downregulation of LOX-5 in neurons, thereby facilitating recovery after spinal cord injury (PANG et al., 2022)

Cells were cultured for 4 days with or without hemin (1 M) and pyruvate (1 mM)