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A 2014 study in Molecular Metabolism demonstrated that MT-2 at 1mg/kg bodyweight in rodent models produced a 31% reduction in 24-hour food intake compared to vehicle controls

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Conversely, inhibiting NNMT allows existing NAD+ (or NAD+ from moderate precursor supplementation) to accumulate, potentially restoring NAD+-dependent pathways more effectively than precursor supplementation alone

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Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets

PMID 9419104