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As coreceptors of innate immunity, TLRs have been thoroughly documented to assume a crucial role in sterile inflammation mediated by extracellular histones functioning as DAMPs [104, 105]

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Its demonstrated that the de novo synthesis of ceramide, the important phospholipid component of ECM, enhances the effect of camptothecin and doxorubicin on FTC therapy, and inhibiting glucosylceramide synthase augments the antitumor effects even better [281]

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Yu YL, An DW, Yang WY, et al