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Studies on semaglutide have found that weight loss tends to increase as the dose increases, and a systematic review and meta-analysis confirmed a dose-response effect, meaning the benefits shift depending on how much you take
Optimal results are seen with a series of six weekly injections
Persistent vomiting or diarrhea can cause dehydration, electrolyte changes, and acute kidney injury
Health - Eur
This double-blind, placebo-controlled study randomized adults with a BMI 30 or 27 plus at least one obesity-related comorbidity (excluding diabetes) who had achieved 5% weight loss after 12 weeks of lifestyle modification to receive tirzepatide or placebo weekly for 72 weeks
Elderly patients with cardiac conditions or those taking loop or thiazide diuretics may be particularly vulnerable
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