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Additionally, GLP-1 RAs can modulate appetite-regulating centers in the hypothalamus, such as directly activating POMC neurons [63] or inhibiting AgRP neurons by acting on GLP-1R-expressing neurons in the dorsomedial hypothalamus [61,63]

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Moreover, the levels of vascular VEGF, angiopoietin, and platelet-derived growth factor (PDGF)-B&D were restored