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Healthcare Systems: As demand for GLP-1RAs grows, governments and healthcare systems will need to consider whether to reimburse new weight-loss drugs and at what cost

221 Further, reduced HIF3A methylation and increased HIF3A levels in blood are associated with IR and higher body mass index (BMI) values in T2DM patients

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This new avenue has yet to see a standout success, with Orforglipron emerging as a leading contender, showing promising results in blood sugar control and weight management according to clinical trials [14][15]