More recent guidance suggests that 12 years may be sufficient for select patients, contingent on oncologic clearance and stable disease markers
The difference in the effects of SLC protein expression on tumor cells and immune cells suggests that targeting the metabolism of tumor cells, inhibiting glutamine uptake by tumor cells, reversing the dominant position of glutamine competition in tumor cells in the TME, and activating immune function to kill tumor cells may be new strategies to explore
doi: 10.1016/j.bbadis.2018.02.003 Summary Keywords IC/BPS, bioinformatics, machine-learning, PLAC8, immune cell landscape Citation Zhou T, Zhu C, Zhang W, Wu Q, Deng M, Jiang Z, Peng L, Geng H, Tuo Z and Zou C (2025) Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning
Rejuvenation Res 2006
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Lower doses could also mean fewer side effects when translated into humans, and combining molecules increases the chances of achieving a biological effect in a genetically heterogeneous population [142]
