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What are study designs and measurement tools and outcomes necessary to answer the question posed in this article

Originally developed for type 2 diabetes, drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have shown remarkable effectiveness for weight management with patients losing 15-20% of body weight in clinical trials

Ongoing monitoring typically involves monthly or quarterly check-ins during dose titration, regular assessment of weight loss progress and tolerability, periodic lab work to monitor metabolic parameters, and screening for potential complications

(113), who demonstrated that in hepatocellular carcinoma (HCC), inhibition of HSP90 significantly promotes the ubiquitination and degradation of the highly expressed RNA polymerase II-associated protein 2 (RPAP2) via the CRL5-FBXW7 E3 ligase complex, thereby suppressing HCC cell proliferation