The current global prevalence of inborn errors of metabolism is approximately 1 in 2000 people, with 2030% of individuals experiencing epilepsy as their primary neurological manifestation [2]
Its often hailed as the bodys master antioxidant due to its unparalleled ability to neutralize free radicals, combat oxidative stress, and protect cells from damage
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Since a Cul3 haploinsufficient mouse model also showed an upregulation of RhoA expression, treatment using the RhoA inhibitor Rhosin was used to successfully rescue these phenotypes in vitro in primary cortical neuron cultures derived from these mice [34]
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