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The symptoms recorded throughout history include convulsions, sores, hallucinations or mania, headaches, nausea, gangrene, and burning extremities.[ref] Modern grain processing methods eliminate ergot as a problem in human food sources, but it can still affect animals that graze on grasses or contaminated grains.[ref] The neuroactive components in the ergot alkaloids are similar to precursor molecules for LSD

While the relationship between serum TMAO and adverse cardiovascular events was established in the general population, TMAO metabolism in CKD has not been completely clarified

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