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Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures

Permeability of nanocarriers across the human BBB co-culture model The permeability of the nanocarriers was investigated on a human co-culture BBB model as shown in Fig

Yet practical protocols use milligram doses, thousands of times higher

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Table 1 summarizes the various studies carried out to evaluate the effects of polyphenol in reversing MDR in cancer cell lines

Treatment is determined by a licensed clinician after review