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The relief of tumor hypoxia broke the chemoresistance and promoted the polarization of tumor-associated macrophages from M2 to M1 type, increasing the efficacy of chemotherapy and immunotherapy

Through the NOX4-ROS pathway, MYC increases nucleotide oxidation, while NUDT1 depletion exacerbates this process, resulting in cell death

59-61 Although actigraphy has been shown in multiple studies to reasonably reflect sleep-wake cycles, compared with polysomnography, it tends to overestimate total sleep time and is more likely to be inaccurate in individuals with poor sleep