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Brightening and even skin tone: Reduces pigmentation, melasma, and dullness caused by sun damage or aging

10.1016/0006-2952(92)90198-R Biochem

Nfr2 and antioxidant genes support a protective system that suppresses inflammation and oxidative damage ( The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) ( Gardeniae Fructus reduces TAA-induced liver fibrosis in mice by activating the Nrf2 and AMPK/SIRT1 pathways

doi: 10.1016/j.freeradbiomed.2019.03.027 160 IrimiaTPucaiuLMitranoviciM-ICrianABudianuMABnescuCet al

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Co-localisation of amyloid plaques and neuroprogenitor fibre tangles with activated glial cells in animal models and human brain tissue