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For patients who have plateaued on maximum-dose semaglutide, switching to tirzepatide is the most evidence-backed next step

Treatment typically begins with lower doses (200 mcg) and increases based on clinical response

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Its multifaceted actions from activating AMPK and improving glucose control to enhancing stress resistance and tissue repair make it a unique biological regulator with broad therapeutic potential

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Most PlexusDx patients lose 24 pounds in their first month, accelerating to 58 pounds monthly as doses titrate upward