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However, supplementation alone is not always sufficient

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Additionally, the need for three times a day administration makes it difficult for patients to comply with these drugs

Abbreviations AIT: Autoimmune thyroiditis CAT: Catalase DIOs: Deiodinases DIO1: Deiodinase type 1 DIO2: Deiodinase type 2 DMGDH: Dimethylglycine dehydrogenase DNA: Deoxyribonucleic acid DUOX: Dual oxidases EnGioI: Young Italian Endocrinologists Group - EnGioI ERK: Extracellular signal-regulated kinase FT4: Free thyroxine GSR: Glutathione reductase GPXs: Glutathione peroxidases GPX1: Glutathione peroxidase 1 HIV: Human immunodeficiency virus H2O2: Hydrogen peroxide H2Se: Selenide IL-1: Interleukin 1 IL-6: Interleukin 6 INMT: Indolethylamine N-methyltransferase gene mRNA: Messenger RNA Met-tRNA: Methionine-translation ribonucleic acid NADPH: Nicotinamide adenine dinucleotide phosphate OS: Oxidative stress O2 : Oxygen 02 * : Superoxide radical PI3K/AKT: Phosphoinositide 3-kinase activation PP: Postpartum RCTs: Randomized control trials ROS: Free radical oxygen species rT3: Reversing triiodothyronine Se: Selenium SeCyS: Selenocysteine SECISBP2: Selenocysteine insertion sequence (SECIS) binding protein 2 3 SeMet: Selenomethionine SELENOK: Selenoprotein K SELENOL: Selenoprotein L SELENON: Selenoprotein N SELENOP: Selenoprotein P SELENOS: Selenoprotein S sFlt-1: Soluble vascular endothelial growth factor receptor-1 SOD: Superoxide dismutase T3: Triiodothyronine T4: Thyroxine Tg: Thyroglobulin TGAb: Thyroglobulin antibodies TH: Thyroid hormone TNF: Tumor necrotic factor TPOAb: Thyroid peroxidase antibodies TRXR: Thioredoxin reductases TSH: Thyroid-stimulating hormone References Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig R, Gladyshev VN

Regular supplementation can also support cardiovascular function, improve cellular regeneration, and increase energy, offering an integrated approach to longevity