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Glutathione also supports investigations on mitochondrial function and age-related oxidative damage
A thiol peroxidase is an H 2 O 2 receptor and redox-transducer in gene activation
In liver cells, methotrexate treatment upregulates LC3II and NCOA4, reduces p62 and FTH1 and triggers ferroptosis
Cellular components including DNA, proteins and membrane lipids are damaged when cells exposed to ROS, RNS, and RCS (Chakraborty et al., 1992
Decreases in oxygen delivery can be compensated for by increasing erythropoietin (Epo) production, which promotes the differentiation of late-stage erythroid progenitors, increasing erythrocytes in the periphery
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