Whilst Wegovy promotes weight loss and improves glycaemic control, prednisolone tends to increase appetite, promote weight gain, and can elevate blood glucose levels
For instance, the scope of GLP-1s is expanding: Zepbound by Eli Lilly was recently approved by the FDA for treatment of sleep apnea in patients with obesity, while Ozempic was greenlit to reduce risk for kidney disease and other conditions
Running both at full dose at the same time would over-inject the shared compounds without adding benefit
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This is a recognised class effect of GLP-1 receptor agonists
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