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While calcium dynamics in both protocols was similar in response to the first step, the response to the second step was significantly reduced following the longstep protocol where the worms had a shorter time period to recover before the start of the second on step (Fig 4A, compare top two panels)

[DOI] [PubMed] [Google Scholar] Koch T., Schulz S., Pfeiffer M., Klutzny M., Schroder H., Kahl E., et al

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Morning dosing may also be preferred by individuals who want to monitor for potential side effects during waking hours when they can more easily manage symptoms or seek medical attention if needed

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Udo Bhm und Friedrich Reuss Gebundene Ausgabe 96 Seiten Auflage 1