The iodinated protein was assembled by increasing concentrations of phase B (Acetonitrile + 0.1% TFA) and tested for competitive binding ability
The study was designed to evaluate weekly berobenatide and included a 28-week primary analysis and a 32-week exploratory extension to investigate higher weekly doses (1.6 mg, 2.4 mg) and less frequent dosing (every other week and monthly [2.4 mg, 3.2 mg, 4.8 mg])
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Daily fluctuations of the concentrations of some parameters recorded in our study additionally complicates the interpretation of the results