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Gambuti, A., Han, G., Peterson, A.L., and Waterhouse, A.L., Am

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This represents complementary rather than redundant mechanisms

A network meta-analysis suggests retatrutides greater efficacy compared to other GLP-1RAs, though head-to-head trials are needed for definitive conclusions

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The latest dual-action GLP-1 analogue, tirzepatide , which also affects GIP receptors, was approved in the US in 2022 as the drug Mounjaro for the treatment of type 2 diabetes, and in 2023 as Zepbound for the treatment of obesity and excess weight, as well as obstructive sleep apnea syndrome in obese individuals