The Endocrine Society's 2020 position statement on peptide therapeutics emphasizes that "the absence of Phase I dose-escalation data for novel peptides like BPC-157 means that any dose recommendation is extrapolated, not validated, and clinicians should err on the side of the lowest effective dose" 19
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Matrine inhibits IL-1-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-B in human chondrocytes in vitro
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