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Ethics declarations Funding This work was supported by the National Natural Science Foundation of China (82103475), Hebei Province Natural Science Foundation (H2023307028, H2024206056), the Medical Science Research Project of Hebei Provincial Health Commission (20240370), Hebei Province Medical Adaptation Technology Tracking Project (GZ2024002), and Hebei Province Government-Funded Clinical Medicine Excellent Talent Training Program (ZF2025013)