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Starting too high often causes nausea, vomiting, and constipation that lead patients to stop treatment

reported that Ipamorelin may potentially elevate growth hormone concentrations up to around 80 mIU/L (equivalent to roughly 27 nanograms per milliliter), representing approximately a 60-fold increase relative to placebo-exposed samples in laboratory conditions

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consequently, physicians in most countries, including those in the CEE region, lack sufficient experience managing these patients [140]