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Reduce appetite and calorie intake

The role of glucagon-like peptide-1 receptor agonists (GLP1-RAs) in the management of the hypertensive patient with metabolic syndrome: a position paper from the Korean society of hypertension

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For example, inulin-type fructans from Platycodon grandiflorus have been shown to stimulate transcription of the anti-inflammatory factors interleukin (IL)-4 and IL-10 in a dose-dependent manner in a porcine jejunum epithelial cell line (IPEC-J2) ( Codonopsis pilosula and Codonopsis tangshen are natural sources of potential antioxidants, which can increase intestinal levels of glutathione peroxidase, superoxide dismutase and catalase, but reduce the levels of malondialdehyde and lactate dehydrogenaseto enhance the antioxidant defense of IECs ( Ruminococcus bromii -producing butyrate is a major source of energy for colonocytes, which contributes to enterocyte proliferation ( In addition to promoting the function of IECs, inulin can promote intestinal barrier function by regulating TJ proteins

These findings suggest that co-targeting the AR and PI3K/AKT pathways may overcome resistance mechanisms and offer a promising therapeutic strategy for advanced, PTEN-deficient prostate cancer [84]

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