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6,7,8,9,10 In breast cancer models, the increased of NAD + pool can be converted to NADPH through the pentose phosphate pathway, thus maintaining glutathione in the reduced state

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However, results from previous studies examining the effects of supplementation with Vitamin C exercise-stimulated oxidative damage have been inconclusive: inhibition of lipid peroxidation [11], no effect [12], and even increased lipid peroxidation [13]

Providers may decline treatment for any clinical reason

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