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This study indicated that riboflavin could significantly decrease 8-hydroxydeoxyguanosine (a biomarker for oxidative DNA damage) in aneurysm walls (Reference Yu, Morimoto and Yu32)

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Immunity 39, 372385

The precise regulation of Drp1 is vital for cellular health, as excessive activation of Drp1 under pathological conditions triggers mitochondrial fission and the release of cytochrome c, ultimately leading to apoptosis [129]

In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)

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