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Efficacy analyses were conducted for 142 patients

While possessing capacity of several diseased targets and of multiple health benefits, polyphenols cover a huge share of global market of nutritional supplements

Those with pre-existing bowel conditions, inadequate fluid intake, sedentary lifestyles, or taking other constipating medications (such as opioids, iron supplements, or certain antidepressants) may be at higher risk

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Notably, the roles of antioxidants in normal physiology are poorly understood, largely preventing our ability to modulate antioxidants to either prevent or treat disease

Any clinical use, where lawful and available, requires individual assessment, supervision and monitoring by an appropriately qualified physician